منابع مشابه
Antiviral T cell responses
Around 700 BCE, a new military formation called the phalanx was established in ancient Greece: a tight column of heavy infantry carrying long spears, or pikes, used in a single prong of attack. Later, in the battle of Marathon described by Herodotus, the Greeks learned the advantages of multipronged attacks, a strategy still used in modern warfare. Is the immune system similar in its approach t...
متن کاملAntiviral Therapy
The current status of antiviral therapy is reviewed, including discussion of older approaches together with more recently developed chemotherapy. Following the introduction dealing with pathophysiological aspects of virus disease, the different approaches to antiviral therapy are presented. The reasons for the slow progress in antiviral therapy are discussed. These include: 1. the necessity of ...
متن کاملMonkeypox virus evades antiviral CD4+ and CD8+ T cell responses by suppressing cognate T cell activation.
Monkeypox virus (MPV) is a virulent human pathogen that has gained increased attention because of its potential use as a bioterrorism agent and inadvertent introduction into North America in 2003. The US outbreak also provided an important opportunity to study MPV-specific T cell immunity. Although MPV-specific CD4(+) and CD8(+) T cells could recognize vaccinia virus (VV)-infected monocytes and...
متن کاملHDAC1 Controls CD8+ T Cell Homeostasis and Antiviral Response
Reversible lysine acetylation plays an important role in the regulation of T cell responses. HDAC1 has been shown to control peripheral T helper cells, however the role of HDAC1 in CD8+ T cell function remains elusive. By using conditional gene targeting approaches, we show that LckCre-mediated deletion of HDAC1 led to reduced numbers of thymocytes as well as peripheral T cells, and to an incre...
متن کاملType 1 Interferons and Antiviral CD8 T-Cell Responses
Type 1 interferons (IFNs) were the first cytokines discovered and include IFNb, .ten forms of IFNa, and several other related molecules that all bind to the same type 1 IFN receptor (IFN1R). Type 1 IFNs are commonly referred to as ‘‘viral’’ IFNs because they can be induced directly by virus infections, in contrast to ‘‘immune’’ IFN, or IFNc, which is synthesized after receptor engagement of T c...
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ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2014
ISSN: 0105-2896
DOI: 10.1111/imr.12138